何氏祛风方治疗尿毒症性皮肤瘙痒疗效分析_刘子洋
刘子洋1 段连香1 刘文瑞1 郭玥1 徐启明1 曹玉1 何立群1* 胡静1*
2023/06/17
【摘要】目的：探讨祛风方治疗尿毒症性皮肤瘙痒症（非透析）的临床疗效。方法：选取上海市第七人民医院肾病科CKD4-5 期患者且符合尿毒症性皮肤瘙痒诊断标准患者共100例，随机分为2 组，治疗组使用祛风方，对照组使用醋酸曲安奈德乳膏，对比两组患者治疗前后皮肤瘙痒及皮疹改善情况，以及观察实验室检查指标WBC、CRP、E%、IL-1β、IL-6，β2-MG 等，并采用SCORAD 评分表及中医证候评分综合评价疗效。结果：两组患者治疗后皮肤瘙痒症状均较前明显改善，且炎性指标、中医证候评分、主要症状疗效率、SCORAD 评分均较治疗前减少（P＜0.05），治疗组总有效率（100%）优于对照组（88%）差异有统计学意义（P＜0.05）；结论：两组治疗均对尿毒症性皮肤瘙保持有效，但祛风方疗效优于对照组。
关键词：尿毒症性皮肤瘙痒;硫代硫酸钠;曲安奈德
Analysis of the therapeutic effect of He’s Qufeng Recipe on Uremia pruritus
Ziyang liu 1 Lianxiang duan1 Wenrui liu1 Yue Guo1 Qiming Xu1 Yu CAO1 Liqun He1* Jing Hu1*
Objective: To explore the clinical efficacy of Qufeng Recipe in the treatment of Uremia pruritus (non dialysis). Methods: A total of 100 CKD4-5 patients from the Nephrology Department of Shanghai Seventh People’s Hospital who met the diagnostic criteria for Uremia pruritus were selected and randomly divided into two groups.
The treatment group used Qufeng Fang, and the control group used Triamcinolone acetonide acetate cream. The improvement of skin pruritus and rash before and after treatment was compared between the two groups, and the laboratory examination indicators WBC, CRP, E%, IL-1 were observed β、IL-6, β 2-MG, and comprehensively evaluate the therapeutic effect using SCORAD scoring table and traditional Chinese medicine syndrome score. Result: After treatment, the skin itching symptoms of both groups of patients were significantly improved compared to before, and the inflammatory indicators, traditional Chinese medicine syndrome score, main symptom treatment efficiency, and SCORAD score were reduced compared to before treatment (P<0.05). The total effective rate of the treatment group (100%) was better than that of the control group (88%), and the difference was statistically significant (P<0.05); Conclusion: Both groups are effective in treating Uremia pruritus, but the effect of Qufeng Recipe is better than that of the control group. Key words: Uremia pruritus; Sodium thiosulfate; Triamcinolone acetonide